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KMID : 0356220020330010055
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Journal of the Korean Military Medical Association
2002 Volume.33 No. 1 p.55 ~ p.62
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The effect of hyperbaric hyperoxia on the pharmacokinetics of caffeine in Korean naval divers
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Abstract
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Background: Diving and hyperbaric oxygen therapy is associated with physiological changes involving the respiratory and cardiovascular system. The effect of hyperbaric hyperoxia on the pharmacokinetics of caffeine was investigated in 4 Korean naval divers.
Method: Some 500 mL of coffee were administered to 4 healthy male volunteers and blood samples were serially collected for 24 h in a normobaric period. After 7-days wash-out period, same coffee were administered to same volunteers and blood samples were serially collected. The volunteers entered a hyperbaric chamber 2.5 h following coffee ingestion for 80 min(30 fsw, 100% O2-breathing). The plasma were analyzed to measure the caffeine concentration by high pressure liquid chromatography. The caffeine amount administered was determined by analyzing an aliquot of the coffee beverage. Pharmacokinetic parameters of caffeine in two different condition were analyzed by non-compartmental methods. Effect of hyperbaric hyperoxia on caffeine disposition were investigated using a non-parametric statistical methods.
Results: All volunteers did not show the adverse reaction relating caffeine administration including oxygen toxicity during a total period of study. Mean AUCTOTAL, CMAX and Cl of normobaric period were 34.27±10.1 ㎍·hr/mL, 4.43±0.64 ㎍/mL and 120.09±37.56 mL/hr, respectively. Mean AUGTOTAL, CMAX and Cl of hyperbaric hyperoxic period were 45.65±9.89 ㎍·hr/mL, 5.72±0.61 ㎍/mL and 85.36±17.83 mL/hr, respectively. The difference of all pharmacokinetic parameters were not statistically significant (p>0.05).
Conclusion: The pharmacokinetics of caffeine do not seem to be influenced in a clinically relevant way in human during a stay for 80 min at 30 fsw, 100% O2, and further investigation is needed to evaluate the subtle effect of hyperbaric hyperoxia on the pharmacokinetics/pharmacodynamic characteristics of caffeine.
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